Graphical AbstractGene editing with engineered nucleases introduce double-strand breaks that are repaired by error-prone nonhomologous end-joining (NHEJ). In article number 1900126, Sara G. Trimidal et al. propose that the length and type or resulting indels can now be controlled by editing with different engineered nucleases or by manipulating the expression of NHEJ genes.

Genome editing with engineered nucleases (GEENs) introduce site‐specific DNA double‐strand breaks (DSBs) and repairs DSBs via nonhomologous end‐joining (NHEJ) pathways that eventually create indels (insertions/deletions) in a genome. Whether the features of indels resulting from gene editing could be customized is asked. A review of the literature reveals how gene editing technologies via NHEJ pathways impact gene editing. The survey consolidates a body of literature that suggests that the type (insertion, deletion, and complex) and the approximate length of indel edits (...) can be somewhat customized with different GEENs and by manipulating the expression of key NHEJ genes. Structural data suggest that binding of GEENs to DNA may interfere with binding of key components of DNA repair complexes, favoring either classical‐ or alternative‐NHEJ. The hypotheses have some limitations, but if validated, will enable scientists to better control indel makeup, holding promise for basic science and clinical applications of gene editing. Also see the video abstract here https://youtu.be/vTkJtUsLi3w. (shrink)

Whole eye transplantation (WET) remains experimental. Long presumed impossible, recent scientific advances regarding WET suggest that it may become a clinical reality. However, the ethical implications of WET as an experimental therapeutic strategy remain largely unexplored. This article evaluates the ethical considerations surrounding WET as an emerging experimental treatment for vision loss. A thorough review of published literature pertaining to WET was performed; ethical issues were identified during review of the articles.

In one of his papers, JC Beall advanced a new and interesting interpretation of Weak Kleene logic, in terms of on-topic/off-topic. In brief, Beall suggests to read the third value as _off-topic_, whereas the two classical values are read as _true and on-topic_ and _false and on-topic_. Building on Beall’s new interpretation, the aim of this paper is threefold. First, we discuss two motivations to enrich Beall’s interpretation, and offer an alternative semantic framework that reflects our motivations. Second, by making (...) use of our new framework, we will offer a new interpretation of the logic of Catuskoti which combines Beall’s proposal of having _FDE_ as the correct logic with the on-topic/off-topic divide. Finally, we will offer a general result that will allow us to make sense of a family of infectious logics in terms of Beall’s on-topic/off-topic reading. (shrink)

In an era where decolonizing architectural pedagogy is imperative, cities stand as the forefront of radical thought, acting as crucibles for ideological, activist, and spatial dynamics. These urban landscapes are not just breeding grounds for new paradigms, but also reflect significant shifts in political and social frameworks. This study adopts the concept of the “radical city” as a prism to understand how local events echo global political and sociocultural disturbances. This research takes an innovative approach by integrating mixed-method pedagogies, student-driven (...) inquiries, and diverse case studies, spanning continents from Asia to Latin America, Europe to Africa, and the US to the UK. The aim is to explore the deep-rooted changes in these cities and to promote a decolonized approach to architectural education, moving beyond traditional, Eurocentric narratives. The backbone of this research is the course “Visualizing Radical Urbanism,” offered at the Huckabee College of Architecture, Texas Tech University, in Fall 2022 and Fall 2023. Through this course, students engage in a pedagogical journey involving exploration, research, analysis, and introspection on their selected radical city. Their diverse methodologies and expressive mediums converge in a comprehensive portfolio, showcasing their intellectual growth and culminating in a reflective essay on their urban subject. By focusing on educational research and time investment in this course, the study highlights the importance of sustained, critical engagement with urban environments. This approach not only enriches architectural education but also contributes to the broader discourse on urban activism and decolonization, reinforcing the need for diverse, inclusive, and globally aware architectural pedagogies. (shrink)

Automated classification of legal documents has been the subject of extensive research in recent years. However, this is still a challenging task for long documents, since it is difficult for a model to identify the most relevant information for classification. In this paper, we propose a two-stage supervised learning approach for the classification of petitions, a type of legal document that requests a court order. The proposed approach is based on a word-level encoder–decoder Seq2Seq deep neural network, such as a (...) Bidirectional Long Short-Term Memory (BiLSTM) or a Bidirectional Encoder Representations from Transformers (BERT) model, and a document-level Support Vector Machine classifier. To address the challenges posed by the lengthy legal documents, the approach introduces a human-in-the-loop approach, whose task is to localize and tag relevant segments of text in the word-level training part, which dramatically reduces the dimension of the document classifier input vector. We performed experiments to validate our approach using a real-world dataset comprised of 270 intermediate petitions, which were carefully annotated by specialists from the 15th civil unit of the State of Alagoas, Brazil. Our results revealed that both BiLSTM and BERT-Convolutional Neural Networks variants achieved an accuracy of up to 95.49%, and also outperformed baseline classifiers based on the Term Frequency–Inverse Document Frequency test vectorizer. The proposed approach is currently being utilized to automate the aforementioned justice unit, thereby increasing its efficiency in handling repetitive tasks. (shrink)

Clinical mental health researchers may understandably struggle with how to incorporate biological assessments in clinical research. The options are numerous and are described in a vast and complex body of literature. Here we provide guidelines to assist mental health researchers seeking to include biological measures in their studies. Apart from a focus on behavioral outcomes as measured via interviews or questionnaires, we advocate for a focus on biological pathways in clinical trials and epidemiological studies that may help clarify pathophysiology and (...) mechanisms of action, delineate biological subgroups of participants, mediate treatment effects, and inform personalized treatment strategies. With this paper we aim to bridge the gap between clinical and biological mental health research by (1) discussing the clinical relevance, measurement reliability, and feasibility of relevant peripheral biomarkers; (2) addressing five types of biological tissues, namely blood, saliva, urine, stool and hair; and (3) providing information on how to control sources of measurement variability. (shrink)

The ordering tendency in binary f -Ti solid solution containing 3sp or 4sp simple-metal or 3d transition-metal solute is investigated systematically by the linear muffin-tin orbital method within the atomic sphere approximation . We demonstrated that the effective pairwise interaction energy in a solid solution is equal to half the solute-solute interaction energies and can be evaluated by a supercell total energy approach. The calculations of EPI energy both with and without volume relaxation of the supercells and local density of (...) states show that the EPI energies of Ti-SM and Ti-TM solutions are dominated by different factors. For Ti-SM solutions, the EPI energies are of large absolute values with a negative sign, indicating strong ordering tendency in these solutions. The volume relaxation does not alter the EPI energy substantially. The calculated LDOS shows that the ordering tendency in Ti-SM solutions may be related to the hybridization between the electrons of the SM atoms when they are close to each other. For most Ti-TM solutions, if calculated without relaxation, the absolute EPI energies are very small; however, if calculated with relaxation, they are of relatively large positive values, indicating a clustering tendency in these solutions. By combining the calculated EPI energy and Flinn's model for short-range order strengthening, the increase in critical shear stress ‰ sro due to SRO is estimated for Ti-SM alloys, and the results qualitatively agree with experiment. (shrink)

PurposeDrawing upon the stimulus-organism-response model, this paper aims to investigate the effects of stores’ environmental components on Chinese consumers’ emotions and intentions to purchase luxury brands.Design/Methodology/ApproachData were collected from Chinese consumers who have purchased luxury brands from retail stores. Partial least squares-structural equation modeling and fuzzy-set qualitative comparative analysis were employed for data analysis.FindingsThe results of PLS-SEM indicated that three dimensions of the store environment directly and significantly influenced Chinese consumers’ emotions. However, fsQCA revealed greater heterogeneity among respondents by highlighting (...) stores’ environmental components and Chinese consumers’ emotions.Originality/ValueThis study makes significant contributions to the marketing literature by examining the S-O-R model alongside fsQCA approach to conditionally predict outcomes in a luxury brand context. The present study may be one of the first to examine the effects of stores’ environmental components on Chinese consumers’ emotions and purchase intentions, applying both symmetrical test and asymmetrical test approaches to determine significant components of the store environment as well as component combinations that predict Chinese consumers’ emotions and purchase intentions. (shrink)

An incline S is a commutative semiring where r+1=1 for any r \in S . We note that the ideal lattice of an S-semimodule is naturally an S-semimodule and so is its congruence lattice when S is transitive. We prove that the categories of complete S-semimodules, together with dual functor, internal hom and tensor product, is a ⋆-autonomous category. We define the locally and globally maximal congruences which are related to Birkhoff subdirect product decomposition. We show that the categories of (...) S-semimodules, algebraic S-semimodules and topological S-semimodules are equivalent. Finally, we get a sheaf representation of any S-semimodule. (shrink)

Faster R-CNN architecture is used to solve the problems of moving path uncertainty, changeable coverage, and high complexity in cold-air induced large-scale intensive temperature-reduction detection and classification, since those problems usually lead to path identification biases as well as low accuracy and generalization ability of recognition algorithm. In this paper, an improved recognition method of national ITR path in China based on faster R-CNN in complicated meteorological systems is proposed. Firstly, quality control of the original dataset of strong cooling processes (...) is carried out by means of data filtering. Then, according to the NITR standard and the characteristics of NITR, the NITR dataset in China is established by the intensive temperature-reduction areas located through spatial transformation. Meanwhile, considering that the selection of regularization parameters of Softmax classification method will cause the problem of probability calculation, support vector machine is used for path classification to enhance the confidence of classification. Finally, the improved faster R-CNN model is used to identify, classify, and locate the path of NITR events. The experimental results show that, compared to other models, the improved faster R-CNN algorithm greatly improves the performance of NITR’s path recognition, especially for the mixed NITR paths and single NITR paths. Therefore, the improved faster R-CNN model has fast calculation speed, high recognition accuracy, good robustness, and generalization ability of NITR path recognition. (shrink)

Given a Polish group G, let $E(G)$ be the right coset equivalence relation $G^{\omega }/c(G)$, where $c(G)$ is the group of all convergent sequences in G. The connected component of the identity of a Polish group G is denoted by $G_0$. Let $G,H$ be locally compact abelian Polish groups. If $E(G)\leq _B E(H)$, then there is a continuous homomorphism $S:G_0\rightarrow H_0$ such that $\ker (S)$ is non-archimedean. The converse is also true when G is connected and compact. For $n\in {\mathbb (...) {N}}^+$, the partially ordered set $P(\omega )/\mbox {Fin}$ can be embedded into Borel equivalence relations between $E({\mathbb {R}}^n)$ and $E({\mathbb {T}}^n)$. (shrink)

Background: Ethical issues pose challenges for nurses who are increasingly caring for patients in complicated situations. Ethical sensitivity is a prerequisite for nurses to make decisions in the best interest of their patients in daily practice. Currently, there is no tool for assessing ethical sensitivity in Chinese language, and no empirical studies of ethical sensitivity among Chinese nurses. Research objectives: The study was conducted to translate the Moral Sensitivity Questionnaire–Revised Version (MSQ-R) into Chinese and establish the psychometric properties of the (...) Moral Sensitivity Questionnaire–Revised Version into Chinese (MSQ-R-CV). Research design: This research was a methodological and descriptive study. Participants and research context: MSQ-R was translated into Chinese using Brislin’s model, and the Translation Validity Index was evaluated. MSQ-R-CV was then distributed along with a demographic questionnaire to 360 nurses working at tertiary and municipal hospitals in Changsha, China. Ethical considerations: This study was approved by the Institutional Review Boards of Yale University and Central South University. Findings: MSQ-R-CV achieved Cronbach’s alpha 0.82, Spearman-Brown coefficient 0.75, significant item discrimination (p < 0.001), and item-total correlation values ranging from 0.524 to 0.717. A two-factor structure was illustrated by exploratory factor analysis, and further confirmed by confirmatory factor analysis. Chinese nurses had a mean total score of 40.22 ± 7.08 on the MSQ-R-CV, and sub-scores of 23.85 ± 4.4 for moral responsibility and strength and 16.37 ± 3.75 for sense of moral burden. Discussion: The findings of this study were compared with studies from other countries to examine the structure and meaningful implications of ethical sensitivity in Chinese nurses. Conclusion: The two-factor MSQ-R-CV (moral responsibility and strength, and sense of moral burden) is a linguistically and culturally appropriate instrument for assessing ethical sensitivity among Chinese nurses. (shrink)

Given a Polish group G, let $E(G)$ be the right coset equivalence relation $G^\omega /c(G)$, where $c(G)$ is the group of all convergent sequences in G. We first established two results: (1) Let $G,H$ be two Polish groups. If H is TSI but G is not, then $E(G)\not \le _BE(H)$. (2) Let G be a Polish group. Then the following are equivalent: (a) G is TSI non-archimedean; (b) $E(G)\leq _B E_0^\omega $ ; and (c) $E(G)\leq _B {\mathbb {R}}^\omega /c_0$. In (...) particular, $E(G)\sim _B E_0^\omega $ iff G is TSI uncountable non-archimedean. A critical theorem presented in this article is as follows: Let G be a TSI Polish group, and let H be a closed subgroup of the product of a sequence of TSI strongly NSS Polish groups. If $E(G)\le _BE(H)$, then there exists a continuous homomorphism $S:G_0\rightarrow H$ such that $\ker (S)$ is non-archimedean, where $G_0$ is the connected component of the identity of G. The converse holds if G is connected, $S(G)$ is closed in H, and the interval $[0,1]$ can be embedded into H. As its applications, we prove several Rigid theorems for TSI Lie groups, locally compact Polish groups, separable Banach spaces, and separable Fréchet spaces, respectively. (shrink)

This paper proposes a new topic in substructural logic for use in research joining the fields of relevance and fuzzy logics. For this, we consider old and new relevance principles. We first introduce fuzzy systems satisfying an old relevance principle, that is, Dunn’s weak relevance principle. We present ways to obtain relevant companions of the weakening-free uninorm systems introduced by Metcalfe and Montagna and fuzzy companions of the system R of relevant implication and its neighbors. The algebraic structures corresponding to (...) the systems are then defined, and completeness results are provided. We next consider fuzzy systems satisfying new relevance principles introduced by Yang. We show that the weakening-free uninorm systems and some extensions and neighbors of R satisfy the new relevance principles. (shrink)

The brain-computer interface based on functional near-infrared spectroscopy has received more and more attention due to its vast application potential in emotion recognition. However, the relatively insufficient investigation of the feature extraction algorithms limits its use in practice. In this article, to improve the performance of fNIRS-based BCI, we proposed a method named R-CSP-E, which introduces EEG signals when computing fNIRS signals’ features based on transfer learning and ensemble learning theory. In detail, we used the Independent Component Analysis algorithm for (...) the correspondence between the sources of the two signals. We then introduced the EEG signals when computing the spatial filter based on a modified Common Spatial Pattern algorithm. Experimental results on public datasets show that the proposed method in this paper outperforms traditional methods without transfer. In general, the mean classification accuracy can be increased by up to 5%. To our knowledge, it is an innovation that we tried to apply transfer learning between EEG and fNIRS. Our study’s findings not only prove the potential of the transfer learning algorithm in cross-model brain-computer interface, but also offer a new and innovative perspective to research the hybrid brain-computer interface. (shrink)

This study aims to investigate the effect of coronavirus disease 2019 on the Chinese public’s mental health during its early stage. We collected the data through an online questionnaire survey. Specifically, we adopted the impact of event scale-revised and state-trait anxiety inventory to assess symptomatic responses to exposure to traumatic life events and public anxiety, respectively, in the COVID-19 pandemic outbreak. Then, we evaluated the differences in the scores among various socio-demographic groups using Kruskal-Wakkis H tests and t-tests and analyzed (...) the IES-R, state anxiety score, and trait anxiety score using the Pearson correlation analysis. Finally, we conducted a path analysis to determine the mediating role of post-traumatic stress disorder symptoms in the relationship between TA and SA. The results show that the average of the SA and TA scores were 48.0 ± 10.4 and 38.0 ± 8.2, respectively; the respondents who suffered from mild, moderate, and severe psychological impacts because of the health crisis accounted for 21.9, 5.2, and 13.1%, respectively; farmers have the highest IES-R score than others; people with the highest income have the lowest SA level; a significant positive correlation existed between the IES-R and STAI scores; and TA produces both direct and indirect effects on SA. Overall, the general Chinese public exhibited much higher anxiety levels than normal in the early days of the pandemic outbreak. Accordingly, we strongly recommend psychological counseling and intervention support to mitigate the adverse psychological impacts of such an event. (shrink)

Sugirtharajah, seorang pakar biblika kelahiran Sri Lanka, yang mengajar di Universitas Birmingham, U.K., dan dikenal sebagai godfather penelitian pascakolonial dalam bidang Alkitab, menambahkan suatu karya inovatif lagi pada daftar tulisan-tulisannya yang sudah sangat mengesankan. Perhatiannya untuk suara penafsiran pinggiran sudah diketahui dari karyanya yang paling terkenal, Voices from the Margin (1991). Meskipun Alkitab berasal dari Asia, namun kebanyakan peneliti-an tentang Alkitab dan juga tentang pengaruhnya sepanjang sejarah, terfokus pada Eropa dan Amerika, dengan meminggirkan Asia. Itu mendorong S (...) untuk mengadakan penelitian tentang Alkitab di Asia, khusus-nya sejarah penerimaannya. Ia menyadari bahwa dampak Alkitab terhadap kebudayaan Asia minim bila dibandingkan dengan pengaruhnya atas kehidupan dan kebudayaan di Eropa. Itu menjadi sangat tampak dalam uraiannya tentang peran Alkitab dalam sastra Asia (bab 7) di mana kutipan, tokoh, dan cerita Alkitab jarang muncul, dan bila ada, lebih banyak dipakai sebagai kritik terhadap kolonialisme Barat atau institusi kekristenan.... S mengakhiri tulisannya dengan menegaskan bahwa prinsip sola scriptura, Alkitab saja, tak punya pasar di Asia yang cenderung membaca Alkitab bersama dengan yang lain, Bhagavad Gita, Dhammapada, Analecta (mengapa di sini Alquran tak disebut S?). Hermeneutika Asia yang diselidiki oleh S, menolak kecenderungan kolonial yang ada baik dalam Alkitab sendiri dan lebih lagi dalam interpretasi kekristenan Barat: Kebudayaan dan masyarakat Asia tidak bergantung pada nilai-nilai kristiani untuk pemerintahan dan pengembangan yang baik.... Di Asia Alkitab adalah salah satu di antara banyak teks yang berwenang (hlm. 259). Tugas kita, menurut S, adalah membebaskan Asia dari klaim monopolistis kitab suci tertentu. Tugas ini mendesak di saat para fundamentalis dari semua agama memakai kitab sucinya untuk membenarkan kekerasannya terhadap yang lain. S bahkan mempertanyakan monoteisme yang dapat menekan perbedaan dan mengabaikan kemungkinan pusat-pusat yang banyak (p. 260). Ia tidak menganjurkan untuk kembali kepada penyembahan banyak dewa-dewi tetapi men-dorong kajian terhadap spirit politeistis yang mendorong toleransi, kemurahan hati, dan koeksistensi. Pembaca tentu bertanya: di mana sesungguhnya posisi S di medan diskusi pluralisme dan inklusivisme, berkaitan dengan cara dialog antaraagama, dan ditantang untuk memikirkan posisinya sendiri. S mengakui bahwa banyak hal mengenai Alkitab di Asia masih perlu diselidiki. Lima belas abad pra-kolonial dibicarakan dalam dua halaman saja. Alkitab yang oleh gereja Nestorian tanpa kekuatan apa pun disebarkan ke India, Sumatra, dan China cuma dihormati tetapi tinggal tidak diterjemahkan selama belasan abad; kabarnya hanya diketahui melalui liturgi. Ada pula kesan bahwa Asia dalam karya S terutama Asia Selatan dan Asia Timur. Asia Tengah (bekas bagian-bagian USSR) memang dari awal tidak dimasukkan dalam penelitiannya, tetapi juga Asia Barat Daya dan Asia Tenggara yang multi-agama hampir tidak disentuh. S mungkin tidak mengetahui beberapa penelitian tentang penerimaan Alkitab di Indonesia yang sudah dipublikasikan oleh Lembaga Alkitab Indonesia. Namun demikian, apa yang disajikan sungguh menarik dan penting, serta membuka mata dan jalan bagi penelitian yang lebih luas. (Martin Harun, Guru Besar Ilmu Teologi Emeritus, Sekolah Tinggi Filsafat Driyarkara, Jakarta). (shrink)

Background Nurses frequently experience ethical issues in their area of practice. In the challenging reality of today’s healthcare environment, nursing students need to be prepared to deal with ethical issues in their future roles. Nevertheless, Chinese nursing students’ ethical sensitivity status and the factors influencing it have not been described. Objective This study aims to explore the level of ethical sensitivity and its influencing factors among Chinese nursing students. Research design This was a cross-sectional study. We firstly cross-culturally adapted the (...) Japanese version of the Ethical Sensitivity Questionnaire for Nursing Students (ESQ-NS) into a Chinese version. Then, we administered the Chinese version of ESQ-NS, the Caring Ability Inventory (CAI), and general information questionnaire to nursing undergraduates. Participants and research context The invitations were sent to 600 nursing undergraduates from four universities in Hunan, China. Ethical considerations The study was supported by the Institutional Review Board (IRB) of the lead university. The Approval No. was E202092. Results A total of 489 undergraduate nursing students participated in the study. The mean score for ethical sensitivity of the samples was 36.34 ± 4.90, and 187.99 ± 22.64 for their humanistic care ability. Pearson’s correlation coefficient test indicated a meaningful and positive relationship between the ethical sensitivity and humanistic care ability (r = 0.576 and p <.01). And regression analysis showed that age, school year, experience in studying nursing ethics, how much you like nursing major, and humanistic care ability were of relevance to nursing students' ethical sensitivity. Discussion Our findings suggest that the mean ethical sensitivity score of Chinese nursing students is 36.34 (13–52). The humanistic caring ability of Chinese nursing students is still at a low level. Conclusion Future interventions for improving the ethical sensitivity of the nursing students should consider general information of participants and their humanistic care ability. (shrink)

This paper begins the last instalment of a six-part project correlating the key aspects of Kant’s architectonic conception of philosophy with a special version of the Chinese Book of Changes that I call the “Compound Yijing”, which arranges the 64 hexagrams (gua) into both fourfold and threefold sets. I begin by briefly summarizing the foregoing articles: although Kant and the Yijing employ different types of architectonic reasoning, the two systems can both be described in terms of three “levels” of elements. (...) Starting at an unnumbered level devoid of any element (the tao or thing in itself), the system proceeds by elaborating a key fourfold distinction (or “quaternity”) on the first level, a twelvefold distinction on the second level, and twelve quaternities (grouped in four quadrants, each with a set of three quaternities) on the third level. Each set of three quaternities (i.e., each quadrant) on the third level corresponds to one of the four “faculties” of the university, as elaborated in Kant’s book, The Conflict of the Faculties. Previous papers have examined the correlations between three key quaternities that Kant defends in relation to each of three faculties (philosophy, theology, and law) and the 12 gua that correspond to that faculty in the Compound Yijing. The final step is to explore the fourth quaternity on the third level, the 12 gua corresponding to the medical faculty. The “idea of reason” in Kant’s metaphysics that guides this wing of the comparative analysis is freedom, and the ultimate purpose of this faculty of the university is to train doctors to care for people’s physical well-being, as free agents imbedded in nature. But this paper will focus only on the four gua that correspond to four basic concepts in Kant’s theory of medicine. The two quaternities in the “yin-yang” (medical) quadrant of the Compound Yijing that will be skipped here are as follows. First, Kant’s account of the idea of freedom itself, which gives rise to the area of traditional metaphysics known as rational cosmology, comes in the first Critique’s Dialectic, in the section on the Antinomy of Reason (CPR A405-567/B432- 595). There he examines four irresolvable issues: whether the world has a beginning in time; whether composite substances consist of simple parts; whether a causality of freedom operates in the natural world; and whether an absolutely necessary being exists. Later I will argue that these correspond to the quaternity consisting of gua 15, 22, 36, and 52. (shrink)

A gauge theory on R×S 3 topology is developed. It is a generalization to the previously obtained field theory on R×S 3 topology and in which equations of motion were obtained for a scalar particle, a spin one-half particle, the electromagnetic field of magnetic moments, and a Shrödinger-type equation, as compared to ordinary field equations defined on a Minkowskian manifold. The new gauge field equations are presented and compared to the ordinary Yang-Mills field equations, and the mathematical and physical (...) differences between them are discussed. (shrink)

Background The ethical competence of head nurses plays a pivotal role in nursing ethics. Ethical climate is a prerequisite for ethical competence, and moral resilience can positively influence an individual’s ethical competence. However, few studies have focused on the relationship between ethical climate, moral resilience, and ethical competence among them. Objectives To investigate the relationship between ethical climate, moral resilience, and ethical competence, and examine the mediating role of moral resilience between ethical climate and ethical competence among head nurses. Design (...) A quantitative, cross-sectional study. Methods A total of 309 Chinese head nurses completed an online survey, including ethical climate questionnaire, Rushton moral resilience scale, and ethical competence questionnaire. Inferential statistical analysis includes Pearson’s correlation and a structural equation model. Ethical considerations This study received ethical approval from the Institutional Review Board of Xiangya Nursing School of Central South University (No. E2023146). Results Head nurses’ ethical climate score positively impacted ethical competence (r = 0.208, p <.001), and ethical climate could affect ethical competence through the mediating role of moral resilience. Conclusion This study emphasized the value of ethical climate in moral resilience of head nurses, ultimately leading to an enhancement in their ethical competence. (shrink)

Background Social responsibility can motivate disaster relief nurses to devote themselves to safeguarding rights and interests of people when facing challenges that threaten public health. However, few studies focused on the relationship of moral courage, job-esteem, and social responsibility among disaster relief nurses. Objective To explore the influence of moral courage and job-esteem on the social responsibility in disaster relief nurses and clarify the relationship model between them. Methods A cross-sectional study was conducted among 716 disaster relief nurses from 14 (...) hospitals in central China through an online survey, including moral courage scale, job-esteem scale, and social responsibility questionnaire. The data were analyzed by Pearson’s correlation, and the mechanism of the effect of moral courage and job-esteem on social responsibility was completed. Ethical considerations This study was approved by the Medical Ethics Committee of the Second Xiangya Hospital of Central South University (Approval Number: 2019016). Results Disaster relief nurses’ moral courage positively impacted social responsibility (r = 0.677, p < 0.01), and moral courage could affect social responsibility through the mediating role of job-esteem. Conclusion Job-esteem mediated between moral courage and social responsibility among disaster relief nurses. Nursing managers regular assessment of nurses’ moral courage and interventions such as meetings and workshops can reduce moral distress, foster morally courageous behavior, enhance job-esteem, and improve social responsibility performance among disaster relief nurses. (shrink)

R. S. Peters on Education and Ethics reissues seven titles from Peters' life's work. Taking an interdisciplinary approach, the books are concerned with the philosophy of education and ethics. Topics include moral education and learning, authority and responsibility, psychology and ethical development and ideas on motivation amongst others. The books discuss more traditional theories and philosophical thinkers as well as exploring later ideas in a way which makes the subjects they discuss still relevant today.

Cortical stimulation has been used for brain mapping for over a century, and a standard assumption is that stimulation interferes with task execution due to local effects at the stimulation site. Stimulation can however produce afterdischarges which interfere with functional localization and can lead to unwanted seizures. We previously showed that cognitive effort can terminate these afterdischarges, when termination thus occurs, there are electrocorticography changes throughout the cortex, not just at sites with afterdischarges or sites thought functionally important for the (...) cognitive task used, and thresholds for afterdischarges and functional responses can change among stimulation trials. We here show that afterdischarge termination can occur prior to overt performance of the cognitive tasks used to terminate them. These findings, taken together, demonstrate that task-related brain changes are not limited to one or a group of functional regions or a specific network, and not limited to the time directly surrounding overt task execution. Discrete locations, networks and times importantly underpin clinical behaviors. However, brain activity that is diffuse in location and extended in time also affect task execution and can affect brain mapping. This may in part reflect fluctuating levels of attention, engagement, or motivation during testing. (shrink)